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A/Pr David Nisbet

Australian National University

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In the Nisbet lab we conduct applied research that sits at the interface between biology and nanotechnology, developing biomaterials to explore both fundamental biological processes and new applications in regenerative medicine. Our research spans broad applications for biomaterials including cell transplantation, organs on a chip, drug delivery and screening, gene therapy, advanced biocompatible and antimicrobial coatings. Such capabilities allow us to tackle several biological problems including neurodegenerative diseases, bone tissue engineering, cancer and infection.

Government Grants: 8

January 1, 2021

Several diseases, including Parkinson’s disease (PD), result in dementia. Currently, pharmacological therapy is the only treatment for PD dementia, which only offers symptomatic relief with diminished efficacy. Therefore, there is a need to develop new strategies that prevent or slow the onset of dementia. This study will utilize nanoscaffolds that facilitate the controlled delivery of therapeutic proteins to prevent or slow the death of neurons associated with dementia in PD patients.

$674K

January 1, 2021

Several diseases, including Parkinson’s disease (PD), result in dementia. Currently, pharmacological therapy is the only treatment for PD dementia, which only offers symptomatic relief with diminished efficacy. Therefore, there is a need to develop new strategies that prevent or slow the onset of dementia. This study will utilize nanoscaffolds that facilitate the controlled delivery of therapeutic proteins to prevent or slow the death of neurons associated with dementia in PD patients.

$665K

January 1, 2020

We will employ peptide inspired hydrogel nanoscaffolds that can be injected into a brain lesion as a single injection to provide chemical and physical support for the surrounding cells. We will utilize various modifications to these materials to reprogram inflammatory cells into neurons, whilst also promoting the survival, maintenance and growth of existing neurons to encourage repair.

$631K

January 1, 2020

We will employ peptide inspired hydrogel nanoscaffolds that can be injected into a brain lesion as a single injection to provide chemical and physical support for the surrounding cells. We will utilize various modifications to these materials to reprogram inflammatory cells into neurons, whilst also promoting the survival, maintenance and growth of existing neurons to encourage repair.

$639K

January 1, 2019

A number of injuries, including stroke, result in tissue loss. Consequently promoting repair will require restoration of tissue structure, replacement cells and a supportive environment to promote integration of these new cells. This study will engineer and develop novel scaffolds that can replace tissue whilst additionally providing physical and chemical support for newly implanted stem cells. This work will be conducted in an animal model of stroke.

$728K

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Patents: 4

March 24, 2014

Transferable high performance nanofilms for self-cleaning

ANU researchers have developed a multi-layered film system with applications as transferable superhydrophobic and superhydrophilic coatings.

Nanostructured coatings have a range of applications in many different fields but current manufacturing processes are costly, complex, require expensive infrastructure and are fabricated directly on the substrate of interest.

Antonio Tricoli and David Nisbet have developed a multi-layered film system that overcomes these limitations, and is based on the well-established, low-cost manufacturing technique of electrospinning.

The current research is focussed on demonstrating the commercial potential of nanocoatings developed using the new process, in particular superhydrophobic (i.e. exceptional at repelling water) and superhydrophilic (i.e. exceptional at spreading water across the surface) coatings that provide self-cleaning, anti-wetting and antifogging/-icing functions.

http://www.anu.edu.au/research/innovation/transferable-high-performance-nanofilms-for-self-cleaning

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Academic Publications: 89

January 1, 2017

Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo

January 1, 2017

Engineering Highly Interconnected Neuronal Networks on Nanowire Scaffolds

January 1, 2016

Controlling integrin-based adhesion to a degradable electrospun fibre scaffold via SI-ATRP

January 1, 2016

Adaptive spatial filtering for off-axis digital holographic microscopy based on region recognition approach with iterative thresholding

January 1, 2016

Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells

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