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A/Pr David Nisbet

Australian National University

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In the Nisbet lab we conduct applied research that sits at the interface between biology and nanotechnology, developing biomaterials to explore both fundamental biological processes and new applications in regenerative medicine. Our research spans broad applications for biomaterials including cell transplantation, organs on a chip, drug delivery and screening, gene therapy, advanced biocompatible and antimicrobial coatings. Such capabilities allow us to tackle several biological problems including neurodegenerative diseases, bone tissue engineering, cancer and infection.

Government Grants: 8

January 1, 2021

Several diseases, including Parkinson’s disease (PD), result in dementia. Currently, pharmacological therapy is the only treatment for PD dementia, which only offers symptomatic relief with diminished efficacy. Therefore, there is a need to develop new strategies that prevent or slow the onset of dementia. This study will utilize nanoscaffolds that facilitate the controlled delivery of therapeutic proteins to prevent or slow the death of neurons associated with dementia in PD patients.

$674K

January 1, 2021

Several diseases, including Parkinson’s disease (PD), result in dementia. Currently, pharmacological therapy is the only treatment for PD dementia, which only offers symptomatic relief with diminished efficacy. Therefore, there is a need to develop new strategies that prevent or slow the onset of dementia. This study will utilize nanoscaffolds that facilitate the controlled delivery of therapeutic proteins to prevent or slow the death of neurons associated with dementia in PD patients.

$665K

January 1, 2020

We will employ peptide inspired hydrogel nanoscaffolds that can be injected into a brain lesion as a single injection to provide chemical and physical support for the surrounding cells. We will utilize various modifications to these materials to reprogram inflammatory cells into neurons, whilst also promoting the survival, maintenance and growth of existing neurons to encourage repair.

$631K

January 1, 2020

We will employ peptide inspired hydrogel nanoscaffolds that can be injected into a brain lesion as a single injection to provide chemical and physical support for the surrounding cells. We will utilize various modifications to these materials to reprogram inflammatory cells into neurons, whilst also promoting the survival, maintenance and growth of existing neurons to encourage repair.

$639K

January 1, 2019

A number of injuries, including stroke, result in tissue loss. Consequently promoting repair will require restoration of tissue structure, replacement cells and a supportive environment to promote integration of these new cells. This study will engineer and develop novel scaffolds that can replace tissue whilst additionally providing physical and chemical support for newly implanted stem cells. This work will be conducted in an animal model of stroke.

$728K

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Patents: 4

March 24, 2014

Transferable high performance nanofilms for self-cleaning

ANU researchers have developed a multi-layered film system with applications as transferable superhydrophobic and superhydrophilic coatings.

Nanostructured coatings have a range of applications in many different fields but current manufacturing processes are costly, complex, require expensive infrastructure and are fabricated directly on the substrate of interest.

Antonio Tricoli and David Nisbet have developed a multi-layered film system that overcomes these limitations, and is based on the well-established, low-cost manufacturing technique of electrospinning.

The current research is focussed on demonstrating the commercial potential of nanocoatings developed using the new process, in particular superhydrophobic (i.e. exceptional at repelling water) and superhydrophilic (i.e. exceptional at spreading water across the surface) coatings that provide self-cleaning, anti-wetting and antifogging/-icing functions.

http://www.anu.edu.au/research/innovation/transferable-high-performance-nanofilms-for-self-cleaning

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Academic Publications: 107

January 1, 2018

Biomaterial systems to resolve brain inflammation after traumatic injury

January 1, 2018

Scaffolds formed via the non-equilibrium supramolecular assembly of the synergistic ECM peptides RGD and PHSRN demonstrate improved cell attachment in 3D

January 1, 2018

Large and small assembly: Combining functional macromolecules with small peptides to control the morphology of skeletal muscle progenitor cells

January 1, 2018

Regenerative Medicine: A Programmed Anti-Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response (Adv. Mater. 50/2018)

January 1, 2018

BIOMATERIALS SUPPORT THE INTEGRATION OF HUMAN EMBRYONIC STEM CELL-DERIVED CORTICAL GRAFTS TO PROMOTE FUNCTIONAL REPAIR IN A MODEL OF FOCAL ISCHEMIA

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